Protein Homology Modeling

Topics covered

• Assessing the limitations and assumptions in protein homology modeling
• Selecting an appropriate protein structural template to create a model
• Aligning your protein target sequence to a protein template sequence
• Building a protein homology model using Discovery Studio 2016 tools
• Analyzing the model in terms of quality, energy and structural features
• Refining the homology model
• Using the homology model for further studies, including mutagenesis studies, protein-protein docking, or ligand docking for structure-based drug design

Prerequisites

Introduction to Discovery Studio