Antibody Modeling
This course instructs students in the application of the new Antibody Modeling Cascade. This method provides for automatic generation of a 3D model structure for antibody Fab or Fv regions starting from a set of five antibody structures. This course also provides instruction in the manual modeling and alignment tools for antibody structure, identifying framework templates and antibody loops, and the use of the Antibody Modeling Cascade. The use of Proteins 3D to verify the modeled antibody structures are also presented. Exercises for students to follow in modeling antibody examples are provided.
- Level
- Fundamental
- Length
- 8 hours
- Product
- Discovery Studio
- Format
- Instructor-ledOnsite or Virtual Classroom
Topics covered
- Introduction to antibodies
- Fab antibody modeling
- Antibody Modeling Cascade
- Identify Framework Templates
- Model Antibody Framework
- Model Antibody Loops
- Graft Fab Structure
- Model Bispecific Antibodies
- Full length antibody modeling
- Minimization
Prerequisites
Related courses
Introduction to Discovery Studio
Protein Homology Modeling
Pharmacophore Modeling in Discovery Studio
Simulations
Common Feature Pharmacophore Generation
Library Design and Analysis
Protein-Protein Docking
QSAR
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