Protein-Protein Docking

This course covers the use of the ZDOCK protein-protein docking software and RDOCK energy rescoring programs available within the Discovery Studio suite. The ZDOCK methodology, as well as algorithms for clustering results are described. Methods for the use of guiding protein-protein docking available within Discovery Studio by filtering residues known experimentally to be involved at the protein-protein interface, as well as excluding those known not to be through blocking, are demonstrated.